Advances in Structural Biology, Vol. 4 by S.K. Malhotra

By S.K. Malhotra

The current quantity maintains the craze demonstrated in earlier volumes during this sequence on Advances in Structural Biology. As long ago, varied issues of present significance correct to the topic of the sequence are incorporated within the fourth quantity.

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Cell Biol. 1985, 1,209-241. ; Saraste, M. FEBS 1992, 307, 55-61. L. Amer. J. Physiol. 1992, 262, G10791086. J. Science 1992, 258, 948-964. K. Cell 1981, 23, 95-103. J. Cell Biol. 1988, 107, 2377-2387. J. Membr. Biol. 1987, 100, 123-136. D. Cell 1992, 71, 359-362. ; Ripoche, P. J. Cell Biol. 1976, 71, 907--920. ; Husain-Chishti, A. Proc. Natl. Acad. Sci. A. 1991, 88, 6595-6599. J. Cell Sci. 1995, 108, 609--619. A. Int. Rev. Cytol. 1974, 39, 191-283. J. Mol. BioL 1992, 224, 1127-1141. J. Cell Sci.

It is estimated that there are approximately 30,000 ZO-1 molecules per MDCK cell. , 1988). Since its identification, ZO-1 has been reported in a wide range of epithelial and endothelial cells, both in 30 ANDREW G. HOWARTH and BRUCE R. STEVENSON vivo and in cultured cell lines. To date, it appears to be a ubiquitous component of tight junctions in vertebrate tissues. , 1995). The functional significance of ZO-1 phosphorylation is not yet clear. , 1994). Phosphorylation events have been implicated in the disruption of tight junctions and the disassociation of ZO-1 from the membrane.

E. Connexin Genes and their Chromosomal Location . . . . . . . Tissue Distribution o f Gap Junctions . . . . . . . . . . . . A. Gap Junctions in the Central Nervous System (CNS) . . . . . . Regulation of Gap Junctions . . . . . . . . . . . . . . A. Calcium Ions . . . . . . . . . . . . . . . . . B. Intracellular pH . . . . . . . . . . . . . . . . C. Cyclic AMP . . . . . . . . . . . . . . .

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